Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity

A tannin, EA (1), and other nine non-tannins compounds, gallic acid (2), quercetin (3), myricetin (4), 3-O-methylellagic acid-4?-O-?-L-rhamnopyranoside (5), quercetin-3-O-?-D-galactopyranoside (6), kaempferol-3-O-?-D-glucoside (7), quercetin-3-O-?-D-glucuronide (8), quercetin-3-O-rutinoside (9), 3,3?,4-tri-O-methylellagic acid-4?-O-?-D-glucopyranosyl (10) were isolated from a valuable medicinal plant, Eucalyptus citriodora. Structural identification of these compounds was conducted using 1H NMR 13C spectroscopy comparing their spectral data with those previously reported in literatures. The anti-inflammatory effects evaluated ethanol-induced acute gastric ulcer mice models our study. result demonstrated that the intragastric administration significantly prevented ulceration caused by ethanol treatments. Especially, tissue middle-dose (100 mg/kg) showed few ulcerations only slight focal congestion which indicated it has significant protective effect on increasing IL-10 PGE2 levels, reducing IL-6, TNF-?, GAS COX-2 levels. In addition, no adverse liver kidney. These findings imply exerts gastroprotective means its may be potential drug for anti-ulcer treatment.